Bioactive from natural ionic compound to a cellulose-based! Summary of \”AM\”: Cellulose-based ionic compound Advances in biomaterials

April 9, the University of Gottingen in Germany Professor Kai Zhang team on \”Advanced Materials\” (Advanced Materials), published online entitled \”Recent Progress on cellulose-based ionic compounds for Biomaterials \”(DOI: 10.1002 / adma.202000717) review papers, systematic summarizes the major bio-based preparation and an ionic compound (cellulose polymers and cellulose nanometers) properties, especially in the field of biomaterials research progress tissue engineering, wound dressings, drug delivery, etc. and it did highlight the potential for future research directions are put forward. Polysaccharide in most organisms play an important role, including human mammals rich in a lot of glycosaminoglycans (GAGs) can effectively regulate the biological mechanisms . However, a limited number of animal-derived polysaccharide commonly available and easily purified, resulting in the serious side effects associated with risk. Cellulose is the most abundant polysaccharide and biocompatible, but for a mammal, and in particular does not have a specific biological activity. Therefore, the development of synthetic / semi-synthetic polysaccharide mimic the polysaccharide found in the human body is an important and has a significant task. The method of zero-current solid phase synthetic polysaccharide still quite expensive, and the purity, low activity, does not apply to large-scale clinical application. And regioselective polysaccharide derivatized to have a functional group similar to the polysaccharide component found in the human body (e.g., a sulfonic acid group, carboxyl group, amino group, etc.), it is possible to obtain a high purity and versatile biomaterials, to reduce the potential of infection and the risk of other adverse side effects. Thus, a cellulose-based compound having a biological activity of living biomaterials development provides an attractive internet. The first review of the structure and function of animal polysaccharides, especially those with specific biomedical applications of human ion characteristics of natural bioactive glycosaminoglycan briefly summarized. Subsequently derivatized cellulose polymer chain and an entry point into the nano-cellulose, respectively, of the sort discussed and their preparation and biological applications cationic and anionic derivatives thereof andTrends and prospects are put forward. This article corresponding author for the Professor Kai Zhang , Dr. Yang Yang is the first author of the paper, Halle University doctoral Yi-Tung Lu and the University of Göttingen Dr. Health has Kui as a common one for. Papers link: https: //onlinelibrary.wiley.com/doi/full/10.1002/adma.202000717