East China University Professor Lin Jiaping team depolymerization made new progress in supramolecular multilevel nanowires

Self-assembly and disassembly is a basic principle in nature nanostructures constructed, while maintaining the set in a reversible process biological body functions, such as aspects of cellular metabolism and self-replication tissue plays an important role. For example, in a cell, globular actin (G-actin) and adenosine triphosphate (ATP) binding in a non-covalent interactions into fine filaments, which fibrils can be depolymerized to generate adenosine diphosphate (ADP ATP hydrolysis by ) and then generates G-actin, recombinant this reversible process and cytoplasmic cell division cycle is crucial. As one of supramolecular chemistry important scientific frontier, Supramolecular Polymerization is an important method for precisely multistage complex nanostructures prepared. However, the reverse process, i.e., depolymerization supramolecular supramolecular structure by decomposition of the assembly unit is less studied, especially supramolecular depolymerization kinetics and mechanism is not clear.

Figure 1. Supramolecular nanowires formed micelles depolymerization unit

Recently, East China University of Prof. Lin Jiaping group reported by the thermal polymerization of supramolecular Nanowire synthesis induced supramolecular depolymerization phenomenon. by a pre-assembled nanowire micelles formed by step polymerization of supramolecular, with increasing temperature, at the node between the nanowire micellar interaction i.e. hydrophobic interaction is destroyed, resulting in a random nanowires depolymerized nanowires cell debris and micelles (see FIG. 1). Transfer between the polymer chains of the micelles occurs accompanied by depolymerization, which is one of the characteristics of such supramolecular depolymerization. The researchers also a theoretical model depolymerization process described supramolecular , kinetic theory shows that supramolecular thermal depolymerization rate constant increases with increasing temperature. Further, with the increase in water content nanowire solution, the interaction between micellar gradually increased, the nanowire solution polymerization becomes difficult. This temperature-induced supramolecular depolymerization in the biomedical field have potential applications. In addition, this work also provides important information for the understanding of the basic principles of supramolecular degradation, and can help design and preparation of complex functional nanostructures of various types. The work by Dr. East China University graduate Gao Hong Bing , postdoctoral sorghum in the Professor Cai Chunhua and Professor Lin Jiaping [1Complete 23] guidance to \”Supramolecular Depolymerization of Nanowires Self-Assembled from Micelles\” was published in Macromolecules (DOI: 10.1021 /acs.macromol.0c00146) In addition, forest Professor Jia Ping team in recent years has made progress in a number of aspects of supramolecular aggregation. The high molecular polymer to expand the concept of the polymerization art supramolecular assembly of supramolecular found and reported micelles of polymerized units, supramolecular cyclized supramolecular living polymerization phenomena . For example, pre-assembled peptides micellar polymerization of graft copolymers formed supramolecular multistage nanowire structure induced at a low temperature, and its kinetic model proposed supramolecular aggregation ( Macromolecules 2019, 52, 7731); Rigid cylindrical micelles formed by block copolymers of the seed growth behavior can occur after the second feed, and made since the liquid crystal driving assembly by a theoretical simulation (LCDSA ) to achieve homogeneity origin supramolecular living polymerization kinetics theory and the supramolecular aggregates ( Nano Letters 2019, 19, 2032). In addition, Professor Lin Jiaping team for the recent multi-stage copolymer self-assembly, in Chemical Review published a report entitled on \”Self-Assembly of Copolymer Micelles: Higher-Level Assembly for Constructing Hierarchical Structure \”review article (see Figure 2), elaborated in recent years, this research team and colleagues progress and prospects copolymer micelles self-assembled , discussed in particular occur at different drive mechanisms polymeric micelle supramolecular behavior, as well as an important role in the theoretical simulation assembly mechanism such as disclosed played.

华东理工林嘉平教授团队在多级纳米线的超分子解聚取得新进展 Figure 2. Self-assembly of multi-stage copolymer

Related work:. 1 Yingqing Lu, Jiaping Lin *, Liquan Wang, Liangshun Zhang *, Chunhua Cai Self-Assemblyof. Copolymer Micelles: Higher-Level Assembly for Constructing HierarchicalStructure Chem Rev. 2020, DOI:.. 10.1021 / acs.chemrev.9b00774 link:. https: //pubs.acs.org /doi/10.1021/acs.chemrev.9b007742. Hongbing Gao #, Liang Gao #, Jiaping Lin *, YingqingLu, Liquan Wang, Chunhua Cai *, Xiaohui Tian. Supramolecular depolymerization of Nanowires Self-Assembled from Micelles. Macromolecules [ 123] 2020, DOI: 10.1021 / acs.macromol.0c00146 link:. https: //pubs.acs.org/doi/10.1021/acs.macromol.0c001463 Hongbing Gao #, Xiaodong Ma #, Jiaping Lin *, Liquan Wang. , Chunhua Cai *, Liangshun Zhang, Xiaohui Tian. Synthesis of Nanowires via Temperature-. Induced Supramolecular Step-Growth Polymerization Macromolecules 2019, 52, 7731-7739 link:. Https: //pubs.acs.org/doi/10.1021/acs.macromol.9b013584. liang Gao, Jiaping Lin, * Liangshun Zhang, Liquan Wang * Living Supramolecular Polymerization of Rod-Coil Block Copolymers:. Kinetics, Origin of Uniformity, and Its Implication Nano Lett 2019.. , 19, 2032-2036 links:. https: //pubs.acs.org/doi/10.1021/acs.nanolett.9b00163