Professor Yang Jian Guo Jinshan Southern Medical University and Pennsylvania State University USA \”AFM\”: Citric acid-based composite material bone tannins bridged to promote bone fusion of the lumbar spine

Natural bone of 60-65wt% of an inorganic component (primarily hydroxyapatite (hydroxyapatite, HA)) embedded in collagen (organic component) in the composition, and therefore, the organic / inorganic composite materials are widely used as bionic artificial bone scaffold. However, the conventional organic / inorganic composite material of the inorganic phase and the organic phase poor compatibility, easily lead to phase separation, to reduce the mechanical properties, as well as osseointegration and bone regeneration effect difference. HA by an amount of the surface graft organic polymers (such as polylactic acid (PLA), poly-amino acids) can improve the compatibility of the organic and inorganic phases. However, these strategies largely limited by surface modification characteristics of the surface of inorganic particles to inorganic and generally require pretreatment necessary. Strategies to develop a universal connection inorganic particles and organic polymer has scientific significance and practical value is very important.

FIG. 1. The silver nanoparticles tannins and modified HA and chemically react with the citric acid-based polymer

mussels (Mussel) or tannin (Tannin) catechol (catechol) adhesion policy inspired employed or gallic acid (gallol) not only by a group forming a covalent bond adhesion strength under oxidative or basic conditions in a biological tissue surface, but also by surface attachment, hydrogen strong inorganic bond or the like adhered to the surface, making it a \”bridging\” molecule preferably between organic and inorganic substances. By a simple, efficient surface modification process, tannin can be strongly adhered to the inorganic phase (HA) surface (silver nanoparticles can be generated in situ and is simultaneously fixed to the surface), and by chemical reaction with the organic phase (citric acid based polymer) to form a covalent bond (FIG. 1), to break the organic and inorganic phase interface to better simulate the natural bone structure, greatly improves the compression of the composite strength (up to 325 MPa) , exceeds the strength of cortical bone of the body (100-230 MPa). Citrate yl developed tannins bridged organic / inorganic composite orthopedic material (citrate-based tannin-bridged bone composite, CTBC) is also full of citric acid-based polymer and a bioactive tannins and silver nanoparticles, having antibacterial, promote biological mineralization, growth and promote cell adhesion,And promoting bone conduction and bone induction activity (FIG. 2). Animal experiments to further verify the effect of promoting CTBC with lumbar fusion for POC-HA and blank control (FIG. 3). Tannins polyfunctional CTBC fixed to the surface retains the biological surface bonding sites can be used to further enhance its biological activity.

Figure 2-yl citrate tannic bridged organic / inorganic composite orthopedic material
Figure 3. The lumbar vertebrae and the bone fusion experiments density results

above findings recently at Citrate-based tannin-bridged bone composites for lumbar fusion was published in Advanced Functional Materials (2020, DOI: 10.1002 / adfm.202002438). The first author of the paper for the Southern Medical Professor Guo Jinshan . Third Affiliated Hospital of Southern Medical University, Xiedeng Hui, associate professor , Southwestern Medical Tian Xinggui as a co-first author. Pennsylvania State University Professor Yang Jian corresponding author, Southern Medical University Professor Bai Xiaochun , Lu Zhihui Research Associate as a co-corresponding author.

Professor Yang Jian Introduction

Yang Jian, Ph.D., Professor of Biomedical Engineering, Pennsylvania State University, and multi-Lloyd Huck Luo Xi Fall regeneration project Professorship (Lloyd & Dorothy Foehr Huck Chair in Regenerative Engineering). Professor Yang Jian focused on innovative research and citric acid-based biomaterials in tissue engineering, drug delivery, biosensors and bio-imaging. He won the 2010 US National Science Foundation Early Career Award (NSF CAREER Award), 2016 was elected to the American Institute of Medical and Biological Engineering (AIMBE) Fellow, 2018, elected to the US National Academy of Inventors (National Academy of Inventors (NAI)) Academy. So far, published journal articles and books and more than 130 chapters, has a number of Chinese, US and international patents, and founded the successful achievements of medical device companies. Professor Yang Jian also served as \”Bioactive Materials\” and co-editor of \”Frontiers in Bioengineering and Biotechnology\” deputy editor. For more information, please visit: https: //

Professor Bai Xiaochun Introduction

Bai Xiaochun, Ph.D., Dean of Medicine, Southern Medical University foundation , Professor of cell Biology Department. Ministry of Education, \”Cheung Kong Scholar\” Distinguished Professor, National Outstanding Youth Fund winner, \”people plan\” scientific and technological innovation leading talent, selected national talents engineering, mainly engaged in the mechanism of bone and joint degenerative diseases, bone and cartilage repair tissue damage Research, Guangdong provincial Key laboratory of bone and joint degenerative diseases director of the past five years, the national Natural Science Foundation of major projects, key projects, 12 projects outstanding Youth, national Science and Technology progress Award, Yunnan provincial Science and Technology progress prize, the Guangdong Provincial Science and Technology progress Award and the Guangzhou Municipal Science and Technology progress Award each one, in Science, J. Cell Biol., Blood, PNAS, Ann. Rheum. Dis., Adv. Sci., Nat. Commun ., published more than 90 papers on PLOS Genet, J. Bone Miner. Res. and other periodicals, he repeatedly cited 3000, and has been reported F1000 recommendation and the national Foundation website. For more information, please visit: http:

Professor Guo Jinshan // Introduction

Guo Jinshan, graduated from China Changchun Institute of applied Chemistry Academy of Sciences (instructor: Huang Yubin, JING Xia Bin, Chen Xuesi (Chinese Academy of Sciences)). Dr. United States after graduation, worked in the University of Texas at Arlington, Pennsylvania State University (co-advisor: Yang Jian teachGrant) and Harvard University (co-advisor: Postdoctoral Research Juan Perez-Mercader) engaged. June 2019 to third-level personnel recruited Southern Medical University, professor, doctoral tutor. Research focused on the biomedical polymer in the soft and hard tissue engineering materials applications, including biomedical adhesive wound dressings and orthopedic materials and bioactive. So far journals, in Adv. Mater., Adv. Funct. Mater., Biomaterials and other published more than 30 papers, book chapters English Chapter 2, a number of Chinese, US and international patents. Recruitment Task Force and postdoctoral research associate , welcomed the letter to inquire: , 020-61648222, QQ (wechat): 123332035.