Rick He Xiaopeng the team: made significant progress in non-antibiotic antimicrobial material, antimicrobial peptides field microspheres
Recently, scientists phased Progress Feilin Jia Nobel Joint Research Center of East China University of Technology professor He Xiaopeng research group has made in the field of biomedical applications, molecular assembly materials, relevant achievements continuously published in the \”American Chemical Society\” and \”German Applied Chemistry\” . Clinically multi-resistant bacteria (superbugs) intractable infection has become one of the primary threats to life and safety of hospital ICU patients, but traditional antibiotics development process is greatly lags behind the resistant bacteria, so how to develop efficient , novel non-antibiotic antimicrobial type of strategy has become a major challenge for the global biomedical problems faced by practitioners. Based on these key clinical problems, the researchers through molecular self-assembly technology, the development of 1) based on the structure of new materials controlled self-assembly of molecular targeted antibacterial materials, and 2) cyclodextrin-based antimicrobial peptide self-assembly of microspheres to achieve a variety of gram-positive and gram-negative vitro\’s super and kill bacteria in the body. Based on the work of the foundation to build the early glycosylation dimensional self-assembling materials and photodynamic and photothermal dual-mode anti-Pseudomonas aeruginosa (Adv. Funct. Mater.2019, 29, 1806986), and Shanghai Jiaotong University research team wheat and Valiant Professor cooperation, the controllable synthesized graphene nanoribbon structure material, to verify its excellent photothermal properties (Angew. Chem. Int. Ed.2018, 57, 3366), and further in collaboration with Prof. Juyoung Yoon Korea Ewha synthesized cationic porphyrin derivatives, by electrostatic interaction, π-π stacking and the like non-covalent, constructed graphene nanoribbons / porphyrin composite through a series of in vitro and in vivo experiments show that the material via binding to the bacterial surface charges attract, and further by light induced thermal performance and light photodynamic porphyrins performance nanoribbons, synergistic inhibition of the growth of a range of Gram-positive and gram-negative resistant bacteria, and is further achieved in mice epidermal infections super efficient removal of bacteria, which is superior to conventional clinical antibiotics (below). Above work for clinical superbug infection provides a class of, relevant results published in the \”German Applied Chemistry\” (Angew Chem Int Ed.2020, DOI:… 10.1002 / anie.201913506). In recent years, the development of antimicrobial peptides have been widely bio-pharmaceutical industryPan concern, however, the biologically active polypeptide compounds generally have poor membrane permeability and in vivo stability defect, based on the above-mentioned problems, the research team and professor of French École normale supérieure de Cachan Juan Xie, professor at University of Texas at Austin Jonathan Sessler cooperation synthesized pyran nitrile derivative modified cyclodextrin with naphthalene bromine / double fluorescein-modified peptide, the use of host-guest to cyclodextrin bromo naphthalene self-assembly and self-assembly of amphiphilic subsequent to construct fluorescence activated antimicrobial peptide microspheres. Compared to non-assembled peptide, polypeptide constructed microspheres may achieve enhanced fluorescence labeled Staphylococcus aureus and Escherichia coli, both bacteria and exhibit a stronger inhibitory effect. In addition, this strategy also proven suitable for enhancing apoptosis in cells fluorescently labeled mitosis to verify controlled morphology such polypeptide microspheres facilitate cellular uptake system (lower panel). Above work published in the \”American Chemical Society\” (J. Am Chem Soc.2020, DOI:.. 10.1021 / jacs.9b11207). above work provides a new chemical strategies to fight the clinical superbugs. In addition, the research team and collaborators invited in the \”Summary of Chemical Society\” (Chem Soc Rev.2020, DOI:.. 10.1039 / c8cs00118a).. And \”Advanced Functional Materials\” (Adv Funct Mater.2020, 10.1002 / adfm.201907906 ) published a review biomedical applications targeting molecule probe and assembly materials, Professor He Xiaopeng also won the 2020 annual Thieme Chemistry Journals Award. The study work was the guidance Tian Academy of Sciences, the relevant biology and microbiology work was supported by Shanghai Institute of Materia Medica Chinese Academy of Sciences researcher Li Jia, on behalf of Professor Chen Jie Zang Yi and Shanghai Jiaotong University researcher guidance and support, mainly graduated from the university research graduate student Yu Zhihao, Jiao Jin Biao, young teachers Dr. Hu Xi Yue collaborate on work supported by the national Natural Science Foundation research programs, outstanding young science foundation, science and technology major projects in Shanghai, the Shanghai international cooperation and exchange projects, \”111\” talent recruitment funding programs.