Shanghai University of Science and Technology Science day two bursts

上海科技大学一天内连发两篇Science Beijing on April 24 morning, the top international academic journal \”Science\” published online at the same time Shanghai University of Science and Technology were the first to complete two units of important research results. Institute of immunochemical research team successfully resolved mycobacteria key Arab glycosyltransferase complex \”target drug – drug\” three-dimensional structure, the first to reveal the role of first-line anti-TB drugs ethambutol the precise molecular mechanism of the target (study long article) ; iHuman Institute research team won an important breakthrough in the study of obesity drugs target, for the first time to resolve human melanocortin atomic resolution crystal structure of the receptor (Research report) 4. After this year\’s Upper Big Branch as the first complete unit and main completed units were in the \”Science\”, \”Nature\”, the \”cells\” have been published 6 important achievements in the field of human health and basic research our university researchers Adds two heavyweight research. 24 am, the school held a media briefing Press Center, school leaders, Institute of Immunology, Institute of Chemistry and iHuman leadership, faculty, science and technology development at the responsible persons attended the meeting, briefed on two outcomes. Party Secretary Li Ru schools insist on relying on new academicians Pudong Zhangjiang, the depth of integration of science and education situation are introduced. Institute of Immunology, Chemistry, Shanghai University of Science and Technology Rao and academician research team after six years of research tackling, first in the world successfully resolved the mycobacteria key Arab glycosyltransferase complex EmbA-EmbB and EmbC-EmbC of \” Drug targets – drug \”three-dimensional structure reveals the molecular mechanism of the first line antitubercular drugs to act on the target ethambutol. The study is published since ethambutol half a century, scientists have for the first time to break the anti-TB \”old traditional medicine\” inhibitory mechanisms at the molecular level, to solve the problem of drug-resistant tuberculosis, the development of new anti-TB drugs has laid an important foundation. Upper Big Branch visiting scholar at Nankai University Dr. Zhang Lu, the HKUST graduate Rao and Dr. Zhao Yao group is co-first author of the paper. Distinguished Professor Rao on families and academicians, professors Gurdyal S. Besra University of Birmingham, the HKUST Associate Professor Li, assistant professor of kingship co-corresponding author for the paper. 上海科技大学一天内连发两篇Science

上海科技大学一天内连发两篇Science
(left) EMBA-EmbB-AcpM2 composite structure with ethambutol; (right) EmbC2-AcpM2 ethambutol composite structure with
completion

This work marks Rao team through years of efforts, substantially overcome several major strategic high ground tuberculosis drug target key areas of known remaining. Currently, the research team is full use of Shanghai University of Science and Technology and the Zhangjiang biomedical industry base advantage, to promote the anti-TB drug research and development, accelerate the transformation of basic research results.

上海科技大学一天内连发两篇Science
Institute of immunochemical Rao and members of the group photo (from left to right: Li Jun, Zhao Yao, Rao, Zhang Lu, kingship)

iHuman Institute of Shanghai University of Science and Technology won an important breakthrough in the study of obesity drugs target, for the first time to resolve human melanocortin receptor 4 (melanocortin-4 receptor, MC4R) and the annular polypeptide ligand complexes SHU9119 2.8 angstrom resolution rate of crystal structure. Researchers first observed functional GPCR Ca2 + binding mode and found to help stabilize Ca2 + receptor – drug candidate complexes, and agonists of endogenous α- melanocyte stimulating hormone (α-melanocyte stimulating hormone, α -MSH) affinity and potency has been greatly improved. Dr. Yu Jing Upper Big Branch Stevens graduate research group is the first author of the article, iHuman founding director of the Institute Professor Raymond C. Stevens and the University of Michigan Roger D. Cone common Corresponding author. 上海科技大学一天内连发两篇Science 上海科技大学一天内连发两篇Science Obesity Drug Targets – Human melanocortin receptor 4 (FIG design drawn by the present Yekaterina Kadyshevskaya) 上海科技大学一天内连发两篇Science Articles of: Raymond C. Stevens, in the static, some studies have shown that MC4R with Zhao Suwen there are mutations of an individual suffering from early-onset obesity, MC4R for the structure and function of research and drug development has been challenging. The outcome has important reference value for the development of obesity drugs for this receptor. The two important studies published at the same time, the Upper Big Branch as the first complete unit and the main unit is completed this year, respectivelyIn \”Science\”, \”Nature\”, \”cells\” published in the field of human health and basic research to achieve important results 8. This is the Upper Big Branch school more than six years paid off, pioneering and innovative crystal, also the HKUST and the strategic layout and the development of national and regional inseparable, insist on relying on Pudong, into an important manifestation of the results of innovation and development of Zhangjiang. 2013, the Shanghai Municipal Government and the Chinese Academy of Sciences in the Pudong Zhangjiang this piece of land of surging scientific and technological innovation, and co-sponsored the construction of the Shanghai University of Science and Technology. Upper Big Branch development has benefited deeply involved in the construction of Shanghai Branch Center, thanks to full integration into the development and opening of Pudong and Zhangjiang National Science Center to build a comprehensive, educational philosophy and innovation also benefited from the advantages of the integration of science and education. Zhangjiang National Science Center focused on a large number of comprehensive scientific and technological innovation of major projects, facilities and universities, research institutes, brings together biomedical, artificial intelligence, integrated circuits and other high-tech industries, but also attracted a large number of high-level creative talent, so that Zhangjiang as the region with the highest concentration of Chinese innovation, full of vitality and passion for innovation. As a major task Zhangjiang center construction of a comprehensive national science, 2016, 2018 Upper Big Branch and the Shanghai Institute of Applied Physics, working closely Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai Institute for Advanced Studies and the team, we have assumed the live cell imaging, soft X ray free-electron laser, super national construction of major infrastructure facilities ultrashort laser devices and hard X-ray free-electron laser devices. These new facilities will work with the existing Shanghai light source, the National protein (Shanghai) facilities together, cutting-edge research has become the world\’s leading multi-platform cluster field of life, matter, and energy. Recently, the school in the life sciences, particularly in the research and development of new drugs based on the structural biology of the emergence of competing high levels of achievement also benefited from strong support of these major scientific and technological infrastructure. Upper Big Branch School of Life Science and Technology, Institute of Immunology, Institute for Chemistry and Life Sciences iHuman three units of the \”Upper Big Branch complex life.\” Since 2016, the first school to complete the units in \”Science\”, \”Nature\”, \”cell\” and other top international academic journals published five each, a total of 15 important research, which focuses on the nine G protein coupled receptor body (GPCR, currently more than 30% of the market in the sale of drugs to target the GPCR) structure function studies, three studies focused on new TB drug target mechanism. These achievements have formed a series of systems, continuous high levelsBreakthrough, Zhangjiang has become a GPCR research Highland international advanced level, and is building an international mechanism tuberculosis and anti-TB drug research Heights. My school more than six years of innovation and development, inseparable from the \”three always adhere to.\” First, always adhere to the \”small-scale, high-level, international research and innovation university\” positioning school, do something, do nothing, the world technological frontier, facing the country and Shanghai major strategic needs, improve disciplines and scientific layout, cutting-edge research and originality in the field of life science, material science, information science; the second is always adhere to the integration of science and education, closely rely on the power of the national innovation strategy and Shanghai Branch of Chinese Academy of sciences Center and build a from the Chinese Academy of Sciences and institutes of joint scientific and technological research, platform sharing, joint training of students, as well as expert hired mutual cooperation mechanisms such as depth, so that the HKUST starting point to achieve in a short period of time more than six years, leapfrog development. Third, always adhere to reform and innovation, to explore the establishment of a modern university governance system in line with the law building world-class universities. Especially in the development of qualified personnel, the HKUST school from the beginning, insisted on not only \”hat\”, not just a reputation, seniority break, set up their own appointment system, promotion system, appraisal system, to the young teacher with full confidence and adequate opportunity and sufficient conditions for a highly motivated, talented young people and potential fully released. Article link: https: //science.sciencemag.org/content/early/2020/04/22/science.aba9102https: //science.sciencemag.org/content/368/6489/428

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